Below are the NCI Cooperative Group active protocol list within the HCC Clinical Trials Network program. If you wish to access the cooperative group protocol documents and updates, please use the cooperative group links below. Protocol documents are available to cooperative group members who have an active username and password. If you are having difficulty accessing a protocol document, contact your research coordinator or the Network office.

last updated October 14, 2011

Disease Site	Coop Protocol Number	Protocol Title	CTN Member
Breast	NSABP B-39/ RTOG 0413	A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) vs. Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer	Georgetown Hospital System PI: Eric Aguero, MD
Breast	ACOSOG Z1031	A Randomized Phase III Trial Comparing 16 to 18 weeks of Neoadjuvant Exemestane (25 mg daily), Letrozole (2.5 mg) or Anastrozole (1 mg) in Postmenopausal Women with Clinical Stage II and III Estrogen Receptor Positive Breast Cancer	Hilton Head Regional Medical Center PI: Virginia Herrmann, MD (closed to accrual)
Genitourinary	RTOG 0534	A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy	Carolina Regional Cancer Center PI: Todd Williams, MD
Thoracic	CALGB 30610/ RTOG 0538	Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide	Georgetown Hospital System PI: Eric Aguero, MD
Breast	ACOSOG Z1071	A Phase II Study Evaluating the Role of Sentinel Lymph Node Surgery and Axillary Lymph Node Dissection Following Preoperative Chemotherapy in Women with Node Positive Breast Cancer (T1-4, N1-2, M0) at Initial Diagnosis	Hilton Head Regional Medical Center PI: Virginia Herrmann, MD   Lexington Medical Center PI: Lynn Tucker, MD   (closed to accrual)
Breast Prostate Multiple Myeloma	CALGB 70604	A Randomized, Phase III Study of Standard Dosing vs. Longer Dosing Interval of Zoledronic Acid in Metastatic Cancer	Lexington Medical Center PI: Steve Madden, MD
Thoracic	SWOG 0819	A Randomized Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/ Bevacizumab with or without Concurrent Cetuximab in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)	Lexington Medical Center PI: Asheesh Lal, MD
Breast	SWOG 1007	A Phase III Randomized Clinical Trial of Standard Adjuvant Endrocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less	Lexington Medical Center PI: Steve Madden, MD
Breast	RTOG 1005	A Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer	Lexington Medical Center PI: Quillin Davis, MD
Breast	NSABP B-46-I	A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women with Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer	Georgetown Hospital System PI: Darren Mullins, MD