Synthesis Unit

The Lipidomics Synthesis Unit is dedicated to the synthesis of sphingolipids and analogs. This laboratory is fully equipped with two hoods for organic chemical synthesis. A separate room for radioactive synthesis set up with a special hood equipped with and a Bioscan TLC plate reader. The synthesis unit also has access to the NMR Facility at MUSC as well as a fully equipped tissue culture room and dedicated office space.

Co-Director, Synthesis Unit
Zdzislaw Szulc, Ph.D.
Research Associate Professor,
Biochemistry & Molecular Biology | 843-792-0755
Staff Scientist
Aiping Bai, Ph.D.
Research Assistant Professor,
Biochemistry & Molecular Biology
Synthesis Unit
Basic Science Building, Room 748
173 Ashley Ave
Charleston, SC 29425

The Synthesis Unit Provides:

  • Total synthesis of natural sphingolipids (4 isomers for each sphingolipid) from the chiral precursors.
  • Design and synthesis of various inhibitors of sphingolipid metabolizing enzymes.
  • Design and synthesis of organelle-targeted Cers and inhibitors of sphingolipid metabolizing enzymes.
  • Design and synthesis of molecular tools for metabolic studies: radiolabeled, fluorescent, and 17C sphingolipids (containing an unnatural 17C-sphingoid backbone).
  • Design and synthesis of molecular tools for determination of enzymatic activities.

Synthetic Development & Compound Classification

Synthetic development and compound classification are based on the recognition of key sphingolipid enzymes.

Chemical Structures (PDF)

Services & Pricing

The Lipidomics Synthesis Unit provides compounds for the collaborative research and compounds for services priced on a customized basis per project. Please contact Zdzislaw Szulc, Ph.D. regarding pricing for your project.

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