Investigator Initiated Clinical Research

MUSC Hollings Cancer Center investigators are pushing science forward with innovative clinical research that brings new treatment, prevention, diagnostic, and symptom management interventions to the patients of South Carolina and beyond. Below is a list of interventional trials developed by HCC researchers with links to the trial-specific information. If you wish to learn more about a specific clinical trial, please contact the study team, or complete a contact form to connect with the HCC Clinical Trials Office.

 

 

Treatment

Phase II Trial of Sparing the Urethra, Pudendal Artery and Rectum During Stereotactic Ablative Body Radiotherapy (SUPR-SABR) for Favorable and Intermediate Risk Prostate Cancer
PI: Harriet Eldredge-Hindy
NCT05668351

Feasibility Trial of Preoperative 5 Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma
PI: Jennifer Harper
NCT05776667

A Randomized Phase II Trial of Consolidation Therapy Following CD19 CAR T Cell Treatment for Relapsed/Refractory Large B Cell Lymphoma or Grade IIIB Follicular Lymphoma
PI: Brian Hess
NCT05633615

A Phase 1b Dose Escalation Study Of Metabolically Fit Cd19 Chimeric Antigen Receptor (Car) T Cells With Cd34 Selection Markers In Adult Patients With Relapsed Or Refractory Cd19 B Cell Non Hodgkin Lymphoma And Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
PI: Brian Hess
NCT05702853

Pembrolizumab In Combination With Anti platelet Therapy For Patients With Recurrent Or Metastatic Squamous Cell Carcinoma Of The Head And Neck
PI: John Kaczmar
NCT03245489

T Reg Function Changes: A Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer
PI: Michael Marrone
NCT05586360

Combination of Autophagy Selective Therapeutics (COAST) in Relapsed Gynecological Cancers, Relapsed Prostate Cancer, or other Advanced Solid Tumors, a Phase I/II Trial
PI: Brian Orr
NCT05036226



Interventional Non-Treatment

A Translational Randomized Clinical Trial of Varenicline Sampling to Promote Smoking Cessation and Scalable Treatment Dissemination
PI: Matthew Carpenter
NCT04525755

Hybrid Type 1 Effectiveness Implementation Trial of a Proactive Smoking Cessation Electronic Visit for Scalable Delivery via Primary Care
PI: Jennifer Dahne
NCT05493254

Addressing Rural Cancer Disparities via Proactive Smoking Cessation Treatment within Primary Care: A Hybrid Type 1 Effectiveness Implementation Trial of a Scalable Smoking Cessation Electronic Visit
PI: Jennifer Dahne
NCT05764759

Evaluation of a Proactive Identification and Digital Mental Health Intervention Approach to Address Unmet Psychosocial Needs of Individuals Living with Cancer
PI: Jennifer Dahne

Scale and Evaluate Smoking Cessation and COPD Screening E Visits to Rural Health Clinics
PI: Jennifer Dahne
NCT06236347

The Effect of a Collaborative Art Therapy and Physical Therapy Intervention on Children Undergoing a Hematopoietic Cell Transplant (HCT): a Randomized Clinical Trial
PI: Cynthia Dodds
NCT05441670

A Multi Site Randomized Clinical Trial Comparing a Brief Tele Cognitive Behavioral Therapy Intervention (BRIGHT) with Attention Control for the Management of Body Image Related Distress Among Head and Neck Cancer Survivors
PI: Evan Graboyes
NCT05442957

Comparing the Effects of Augmented Doses of Nicotine Replacement Therapy on Quitting Cigarettes and E cigarettes
PI: Amanda Palmer
NCT06087328

Optimizing Tobacco Treatment Delivery for People Living with HIV
PI: Alana Rojewski
NCT05019495

Adequacy for molecular analysis in EBUS TBNA specimens vs. liquid biopsies in patients with NSCLC, aka, \"The Liquid Trial\"
PI: Gerard Silvestri

Impact of cigarette and e cigarette menthol regulation on current smokers of menthol cigarettes.
PI: Tracy Smith
NCT05896033

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
PI: Tracy Smith
NCT06118502

A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivor Caregiver Dyads
PI: Katherine Sterba
NCT05811936

Contingency Management to Promote Smoking Abstinence in Cancer Patients
PI: Benjamin Toll
NCT04605458