Clinical Trials

Sponsor: MUSC

Sponsor Study ID: 103352

Study Title: Combination of Autophagy Selective Therapeutics (COAST) in Relapsed Gynecological Cancers, Relapsed Prostate Cancer, or other Advanced Solid Tumors, a Phase I/II Trial

NCT Number: NCT05036226

Phase: I/II

Protocol Type: Treatment

Age Group: Adults

Disease Sites: Lip, Oral Cavity and Pharynx, Esophagus, Colon, Anus, Larynx, Bones and Joints, Corpus Uteri, Other Female Genital, Prostate, Eye and Orbit, Brain and Nervous System, Breast, Cervix Uteri

Study Objectives: Autophagy is a cancer cell survival mechanism that is involved in cancer growth, treatment resistance, and metastasis. Hydroxychloroquine and nelfinavir mesylate are agents that inhibit the process of autophagy. Metformin, dasatinib, and sirolimus stress autophagy.

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Study Documents    
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