Clinical Trials

Sponsor: Mersana Therapeutics, Inc.

Sponsor Study ID: MER-XMT-1536-1

Study Title: A Phase 1b/2, First in Human, Dose Escalation and Expansion Study of XMT 1536 In Patients with Solid Tumors Likely to Express NaPi2b

NCT Number: NCT03319628

Phase: I

Protocol Type: Treatment

Age Group: Adult

Disease Sites: Cervix Uteri, Other Female Genital, Ovary

Study Objectives: First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with tumor types likely to express NaPi2b were enrolled in dose escalation. Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) are being enrolled in the expansion segment of this study. Patients with platinum-resistant, high-grade serous ovarian cancer are being enrolled in the UPLIFT segment of this study. In addition to safety assessments, the pharmacokinetics of the drug will be assessed along with ADC activity.

For more information about the trial above please contact the study team:

Trial opened at the following institutions: Medical University of South Carolina

Study Documents
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