Clinical Trials

Sponsor: Tizona Therapeutics, Inc

Sponsor Study ID: TTX-080-001

Study Title: A First in human, Phase 1 Study to Evaluate the Safety of TTX 080, an HLA G Antagonist, in Subjects With Advanced Solid Tumors

NCT Number: NCT04485013

Phase: I

Protocol Type: Treatment

Age Group: Adult

Disease Sites: Bladder, Breast, Cervix Uteri, Colon, Kidney, Larynx, Lip, Oral Cavity and Pharynx, Melanoma, Skin, Other Female Genital, Other Urinary, Ovary

Study Objectives: This is a Phase 1, multicenter, open-label, multiple-dose, dose-escalation and dose-expansion study to evaluate the safety, tolerability, PK, and pharmacodynamics of TTX-080 monotherapy in subjects with advanced or metastatic solid tumors known to express HLA-G. This first-in-human (FIH) study has been designed to evaluate the safety, tolerability, and preliminary antitumor activity of TTX-080 as monotherapy in adults with unresectable or metastatic solid tumors known to express HLA-G.

For more information about the trial above please contact the study team:

Principal Investigator, John Kaczmar, at kaczmar@musc.edu, or please call +1 843-792-6691.
Study Coordinator, Carly Fecio, at fecio@musc.edu.

Trial opened at the following institutions: Medical University of South Carolina

Study Documents
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