Clinical Trials
Sponsor:
Sponsor Study ID:
Study Title:
Feasibility Trial of Preoperative 5 Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma
NCT Number:
NCT05776667
Phase:
II
Protocol Type:
Treatment
Age Group:
Adults
Disease Sites:
Soft Tissue
Study Objectives:
To determine the feasibility of preoperative 5-day HFRT for extremity STS within the HCC patient population
Secondary Objectives:
To evaluate the rates of favorable pathologic response, major woundcomplications, local control, acute toxicity, and 1-year late toxicity
associated with preoperative 5-day HFRT
Exploratory Objectives:
To compare the socio-demographic profile of trial participants with those
of extremity STS patients who would have meet trial criteria and were
offered preoperative CFRT in the 3 years prior to the study opening at HCC
To compare the retention rate for radiotherapy at HCC in patients meeting
trial criteria during the prior 3 years with the retention rate for
radiotherapy during the study period
To compare serum levels of SFRP2 before and after preoperative 5-day
HFRT
To evaluate changes in serum SFRP2 levels before and after preoperative
5-day HFRT for an association with favorable pathologic response
To evaluate patient satisfaction with the decision to participate in a trial of
preoperative 5-day HFRT
To assess the importance of the shorter duration of radiotherapy in an
individual patient s decision to participate in the study
Study Documents
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