Dual use of combustible and electronic cigarettes: A fine grained naturalistic cohort study to investigate dynamic use patterns and trajectories that lead to smoking cessation

Sponsor:

NIH/NIDA

Sponsor Study ID:

R01DA061566

CTO #:

104049

NCT Number:

Phase:

N/A

Protocol Type:

Supportive Care

Age Group:

Adults

Disease Sites:

Study Objectives:

Aim 1: Describe day-to-day variability and longitudinal trajectories in tobacco product use and abstinence over time within cohorts of dual users, exclusive cigarette smokers, and exclusive e-cigarette users. Aim 1 is purely descriptive but will use rigorous methods to: 1) illustrate e-cigarette and cigarette use behaviors (using pixel graphs), 2) quantify dynamic variability in e-cigarette and cigarette use (using dynamic structural equation modeling; DSEM), and 3) classify profiles of cigarette and e-cigarette use dynamics (using latent profile analysis; LPA), each done: a) rigorously for 3 months and b) episodically across monthly 7-day serial bursts over 1 year. Aim 2: Compare variability of tobacco use patterns between dual users, exclusive cigarette smokers, and exclusive e-cigarette users. Hyp 2a: Comparing DSEM parameters identified in Aim 1, dual users will have greater variability in days of cigarette smoking vs. abstinence than exclusive smokers and (Hyp 2b) greater variability in days of e-cigarette use vs. abstinence than exclusive e-cigarette users. Aim 3: Among dual users alone, identify patterns of e-cigarette use that predict cigarette abstinence. Hyp 3a: Comparing LPA groups identified in Aim 1, profiles involving greater magnitude and consistency of e-cigarette use during the initial 3-months of nightly surveys will predict greater CO-verified 7-day point-prevalence cigarette abstinence at the 6- and 12-month follow-ups. Hyp 3b: The same e-cigarette use characteristics during the initial 3-months will be positively associated with number of days of cigarette abstinence from months 4 - 12. Exploratory: E-cigarette characteristics (device, % nicotine, flavor) and/or cannabis use may moderate findings.

eConsent:

Not available

Study Documents:

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