Biorepository & Tissue Analysis Shared Resource

The Biorepository & Tissue Analysis (BTA) Shared Resource provides investigators with access to meticulously collected and annotated human specimens as well as advanced human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared resource comprises several integrated components, e.g., biospecimen and data repository, customized and readily available tissue microarrays (TMAs), laser capture microdissection, matrix-assisted laser desorption/ionization (MALDI) tissue imaging and research pathology services such as histologic analysis of fixed, frozen, and stained tissues and analysis of experimental results.

Steven L. Carroll, M.D., Ph.D.
Professor and Chair,
Department of Pathology & Laboratory Medicine
Operations Manager
Brittany Ivey, Ph.D.
843-876-2319 | 843-876-2346 (fax)
Bioengineering Building 421


Kiki Gibbs, Biorepository Shared Resource 1. Populate a central biospecimen and data repository

  • Collect, process, and store human tissues according to established standard operating procedures (SOPs) with quality control verified by experienced pathologists at the time of accession.
  • Collect, process, and store saliva, urine, plasma, buffy coat, and other protocol-specific human biospecimens at the time of surgery/procedure according to established SOPs.
  • Link clinicopathologic data for each human specimen for research use.
  • Provide custom human TMAs in a cost-effective manner.

2. Provide, develop and modify tissue analysis services to support cancer research (human and animal)

  • Routine and custom staining procedures.
  • Laser capture microscopy.
  • DNA/RNA/protein isolation.
  • MALDI tissue imaging and advanced molecular analysis by mass spectrometry.


The BTA offers a wide range of services for investigators.  Please note prior to services being performed, the requestor must submit an Order Form (PDF). Upon receipt, the operations manager will contact the requestor, review the request, request additional information if needed and provide a pricing proposal. Please note: all requests for specimens undergo committee review for approval.

BTA Services 

IRB Applications

A guide has been developed to assist investigators in determining what Internal Review Board (IRB) category is appropriate for their research. Please review prior to submitting your application.

IRB Submission Process

Equipment & Instrumentation

The Biorepository & Tissue Analysis Shared Resource is fully equipped with the technology to assist investigators in tissue analysis, biospecimen and data repository and tissue microarrays as well as the expertise to perform these services.

BTA Equipment

Publication Acknowledgement

If you publish a manuscript including research supported by the Biorepository & Tissue Analysis Shared Resource, the HCC recommends the following text to be placed in the acknowledgement section: "Supported in part by the Biorepository & Tissue Analysis Shared Resource, Hollings Cancer Center, Medical University of South Carolina."

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