The Lipidomics Shared Resource at MUSC represents expertise specializing in sphingolipid biology, providing services to the Medical University of South Carolina and institutions or industries throughout the world. The Lipidomics Shared Resource is composed of analytical and synthetic units providing expertise, synthetic compounds/standards, and analytical methodology (LC-MS/MS) to enhance an understanding of the role of bioactive lipids in cell (cancer) biology.
The Lipidomics Shared Resource builds on the unique expertise of key personnel in sphingolipid chemistry, analysis, and biology providing intellectual and physical resources to enhance the understanding of bioactive sphingolipids and lipids in signal transduction and cell regulation.
Sphingolipids are recognized as key components regulating fundamental cell biology processes regulating transmembrane signaling. Diversity of bioactive sphingolipids and their interconnected metabolism provide a network of pathways. Key sphingolipid metabolites are: ceramides (Cer), sphingosine (Sph), sphingosine 1-phosphate (S1P), and ceramide 1-phosphate (Cer1P).
The Lipidomics Shared Resource is designed to support research in lipidomics by providing advanced methodology and expertise for both synthesis and analysis of bioactive lipids in a cost-effective manner, with a focus on several key areas:
The following text must be placed under the Acknowledgements section of publications:
“Supported in part by the Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313 and P30 GM103339)”.