The scientific goals of the Hollings Cancer Center Cancer Biology Program are to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins and signaling pathways that mediate the altered phenotypes of cancer cells.
Professor and Chair of Biochemistry & Molecular Biology
College of Medicine
Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina (MUSC) find. A key part of the circadian clock opposes this process, according to a paper published online Dec. 11 in Nature Cell Biology.
Dr. Yiwen Bu and Dr. J. Alan Diehl are hoping their research will lead to a way to restore a cancer cell's biological clock and give cancer patients a better chance at survival.