Cancer Biology Research Program

The scientific goals of the Hollings Cancer Center Cancer Biology Program are to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins and signaling pathways that mediate the altered phenotypes of cancer cells.

Philip H. Howe, Ph.D.

Dr. Philip H. Howe

Professor and Chair of Biochemistry & Molecular Biology

College of Medicine

Academic Focus

  • Cytokine signaling in cancer
  • Cancer stem cells

 Research Profile

CGMR program themes

Featured Research

Dr. Yiwen Bu and Dr. J. Alan Diehl

Cancer overrides the circadian clock to survive

Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina (MUSC) find. A key part of the circadian clock opposes this process, according to a paper published online Dec. 11 in Nature Cell Biology.

Dr. Yiwen Bu and Dr. J. Alan Diehl are hoping their research will lead to a way to restore a cancer cell's biological clock and give cancer patients a better chance at survival.

Shared Resources

To ensure cancer investigators have access to specialized technology and research services, the Hollings Cancer Center supports shared resources that are efficient, cost-effective and provide the latest industry standards for enhanced scientific productivity.

Shared Resources

Back to top Back to top