Developmental Cancer Therapeutics Research Program

The scientific goal of the Developmental Cancer Therapeutics Program is to discover and characterize unique agents and pathways that will impact the development of more effective cancer therapies and to translate these discoveries into clinical applications by using proof-of-principle, early phase clinical and correlative science studies.

Michael B. Lilly, M.D.

Michael  B. Lilly, M.D.

Professor of Medicine

College of Medicine

Academic Focus

  • Genitourinary malignancies
  • Acute leukemia

 Research Profile

Besim Ogretmen, Ph.D.

Dr. Ogretmen

Professor of Biochemistry & Molecular Biology

College of Medicine

Academic Focus

  • Sphingolipid metabolism; Lipid signaling
  • Cancer cell death pathways
  • Mechanisms of cancer therapeutics

 Research Profile

Featured Research

Besim Ogretmen, Ph.D.

What does hair loss have to teach us about cancer metastasis?

An innovative study looking at hair loss in a preclinical model reveals clues to how cancer spreads in a recent issue of Science Signaling.

Researchers at the Medical University of South Carolina (MUSC) have identified one mechanism that regulates signaling events leading to cell migration and metastasis, showing that primary cilia act as a focal point to transmit growth signals. They also identified a specific ceramide species (produced by ceramide synthase 4 [CerS4]) that disrupts the ability of cells to form this focal point.

Additional Research Programs

Shared Resources

To ensure cancer investigators have access to specialized technology and research services, the Hollings Cancer Center supports shared resources that are efficient, cost-effective and provide the latest industry standards for enhanced scientific productivity.

Shared Resources

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