Supportive Oncology/Cancer Care Delivery Trials
Every treatment that has ever made a difference in cancer care was once a part of a clinical trial. MUSC Hollings Cancer Center is committed to offering the best treatments available today while searching for even better ones for the future. Ask your doctor if a clinical trial is right for you.
STUDY17550
Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS)
To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the Brief Pain Inventory (BPI)) and pain interference (also measured by the BPI) from baseline to the post-intervention assessment for cancer survivors with persistent pain.
Study InformationSTUDY12888
The Impact of a Gravity versus Vacuum Based Indwelling Tunneled Pleural Drainage System on Pain: A Multicenter, Randomized Trial
The objective of this investigation is to compare different drainage strategies of Indwelling Pleural Catheters (IPC) regarding patient quality of life and outcomes
Study InformationSTUDY19497
A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivor-Caregiver Dyads
To evaluate the effects of SNAP on: a) caregiver burden in caregivers, b) symptom severity in survivors and c) psychological well-being in head and neck cancer survivors and caregivers 6 months after completing SNAP
Study InformationSTUDY19843
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced adenomas randomized to surveillance colonoscopy at 10 years compared to participants randomized to surveillance colonoscopy at 5 and 10 years.
Study InformationSTUDY18274
A Multi Site Randomized Clinical Trial Comparing a Brief Tele Cognitive Behavioral Therapy Intervention (BRIGHT) with Attention Control for the Management of Body Image Related Distress Among Head and Neck Cancer Survivors
To evaluate the efficacy of BRIGHT compared with attention control (AC) on HNC-related BID as measured by change from baseline in the IMAGEHN score.
Study InformationSTUDY22933
A Stepped Wedge Cluster Randomized Trial Comparing a Navigation-Based Multilevel Intervention With Treatment as Usual to Improve Initiation of Timely Postoperative Radiation Therapy in Adults with Locally Advanced Head and Neck Squamous Cell Carcinoma (The ENDURE Trial)
Primary Objective: 1. To evaluate the effectiveness of ENDURE compared with TAU on the initiation of timely, guideline-adherent PORT among patients with LAHNSCC undergoing surgical therapy with a pathologic indication for PORT as measured by the proportion of patients who initiate PORT within 6 weeks of surgery. Secondary Objectives: 1. To evaluate the effectiveness of ENDURE compared with TAU on the timely initiation of PORT among patients with LAHNSCC undergoing surgical therapy with a pathologic indication for PORT as determined by (1) median time-to-PORT initiation following surgery and (2) treatment package time. 2. To assess the effectiveness of ENDURE compared with TAU on racial disparities in the timely initiation of PORT among Black and White patients with LAHNSCC undergoing surgical therapy with a pathologic indication for PORT as determined by (1) the proportion of patients who initiate PORT within 6 weeks of surgery; (2) median time-to-PORT initiation following surgery; and (3) treatment package time. 3. To evaluate the effect of ENDURE compared with TAU on resolving barriers to timely PORT. 4. To compare the effect of ENDURE compared with TAU on satisfaction with cancer care as determined by Patient Satisfaction with Cancer Care scores. 5. To examine the mechanism through which ENDURE reduces treatment delays compared with TAU as measured by key (1) processes of cancer care delivery and (2) health behavior constructs at the patient and team levels. 6. To characterize the implementation outcomes related to fidelity, adaptation, acceptability, appropriateness, and feasibility of ENDURE across diverse care delivery settings. Primary Endpoint: PORT delay, defined per National Comprehensive Cancer Network (NCCN) Guidelines as the initiation of PORT > 6 weeks (42 days) following definitive surgery for HNSCC. Select Secondary Endpoints: Time-to-PORT initiation, defined as the number of days from the date of definitive surgery for HNSCC to the date of initiation of PORT. Treatment package time, defined as the number of days from the date of definitive surgery for HNSCC to the date of PORT completion. Patient Satisfaction with Cancer Care score. Pre-surgical radiation consultation, defined as the attendance by the patient at a consultation with the treating radiation oncologist prior to surgery to discuss radiation therapy in the definitive or adjuvant setting. Pre-radiation therapy dental extractions, defined as the extraction of indicated carious/non-restorable teeth prior to or during definitive surgery. Time from surgery to PORT referral, defined as the time, in days, from the date of the definitive surgical procedure to the date the referral (or postoperative appointment) is placed to discuss adjuvant therapy with the treating radiation oncologist. Time from PORT referral to appointment, defined as the time, in days, from the date of the definitive surgical procedure to the date that the patient attends a postoperative appointment with radiation oncology.
Study InformationSTUDY25004
Improving Proactive Approaches for Cancer Survivors' Mental Health Treatment
To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on depression symptom severity among ILLIC with depression as measured by the change in the PHQ-9 score from baseline. To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on anxiety and quality of life among ILLIC with depression as determined by the (1) change in the Hospital Anxiety and Depression Scale, Anxiety subscale score from baseline and (2) change in the Functional Assessment of Cancer Therapy-General score from baseline.
Study InformationSTUDY25353
NRG-CC012CD: Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment (Symon)
Test the effectiveness of automated telephone system management (ATSM) + telephone interpersonal counseling (TIPC) versus active control on patient level outcome of the summary toxicity index of 24 PRO-CTCAE symptoms that include depressive, anxiety, and other symptoms commonly experienced during oral anti-cancer treatment over weeks 1-12 (immediate effect) and 13-17 (sustained effect).
Study InformationSTUDY25400
Exploratory Analysis of Metastatic Gynecologic Cancer Patient Experiences of Symptom Management in a Diverse Southeastern Population
The purpose of this study is to explore how socioeconomic status, race, and clinical variables affect gynecologic cancer patients perceived experiences with symptom management. The goal of this analysis is to understand patients undergoing cancer directed therapy who are underrepresented in clinical trials experience with symptom management and symptom burden. Hypothesis: Demographic and socioeconomic data in patients undergoing treatment for metastatic gynecologic cancer will have unique perceived experiences regarding their symptom management. These experiences will change how patients interact with the healthcare system as indicated by direct clinical variables such as direct admissions to the hospital for symptom management and prescribing factors.
Study InformationSTUDY25488
Priorities, Preferences, and Tradeoffs Among Older Adults with Oropharyngeal Cancer
To characterize the impact of aging and multimorbidity on treatment priorities and preferences among patients with OPC.
Study Information