Supportive Oncology/Cancer Care Delivery Trials
Every treatment that has ever made a difference in cancer care was once a part of a clinical trial. MUSC Hollings Cancer Center is committed to offering the best treatments available today while searching for even better ones for the future. Ask your doctor if a clinical trial is right for you.
STUDY25923
A Stepped-Wedge Randomized Trial Using Multi-Faceted Surgeon-Focused Education to Evaluate the Impact of a Decision Support Tool and VTE-related Pre-Discharge Education to Increase Adherence to Guideline-Concordant Extended Venous Thromboembolism Prophylaxis After Major Abdominopelvic Cancer Surgery.
Characterize barriers and facilitators to ePpx guideline adherence as perceived by stakeholders via key informant interviews with a diverse group of patients and surgeons at four hospitals within the MUSC Health system that routinely perform abdominopelvic cancer surgery. Conduct a stepped-wedge randomized trial including multi-faceted surgeon-focused education and academic detailing to evaluate the impact of an EMR-based CDSS to increase adherence to ePpx guidelines at the three selected hospitals.
Study InformationSTUDY25980
Optimizing Care for Cancer Survivors with Depression (OASIS): Project 3
Via a pilot randomized clinical trial (N=45, randomized 2:1), examine the feasibility of a digitally-enhanced stepped care approach to depression treatment among cancer survivors. Describe the efficacy of digitally-enhanced stepped depression care as compared to guideline-concordant standard care among cancer survivors.
Study InformationSTUDY26061
Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors
To evaluate the feasibility of text message-based to depression screening among cancer survivors.
Study InformationSTUDY26247
Pilot Feasibility Trial to Evaluate a Technology-Enabled Approach to Enhance Depression Referral Uptake Among Cancer Survivors
To evaluate the feasibility and acceptability of a technology-enabled approach to improve referral uptake among cancer survivors.
Study InformationSTUDY26465
Complementary Options for Symptom Management In Cancer (COSMIC): Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among a Cohort of Cancer Patients Treated in Community Oncology Clinics
To examine the association between cannabis and/ or cannabinoid use and cancer related symptoms associated monthly for one year in adults newly diagnosed with breast, colorectal, melanoma, non-hodgkin lymphoma, or non-small cell lung cancer who are planning or recently started to receive one or more systemic cancer directed therapies with chemotherapy and/or immune check point inhibitors targeting PD-1, PDL1 or CTLA-4.
Study InformationSTUDY26531
NRG-CC014 Radiation Therapy for High-Risk Asymptomatic Bone Metastases: A Pragmatic Multicenter Randomized Phase 3 Clinical Trial (Preempt)
1. OBJECTIVES 1.1 Primary Objective To determine whether prophylactic radiation therapy (RT) to high-risk asymptomatic bone metastases decreases the occurrence of skeletal-related events (SREs), including pathologic fracture, spinal cord compression, and surgery to bone (not including palliative radiation for pain only), compared to standard of care (SOC). 1.2 Secondary Objectives 1.2.1 To compare overall survival (OS) between study arms. 1.2.2 To compare occurrence of any SREs (including RT for palliation of pain) among enrolled bone metastasis(es) between study arms. 1.2.3 To compare occurrence of hospitalizations related to any SREs in enrolled bone metastasis(es) between study arms. 1.2.4 To compare pain-related quality of life (QOL) between study arms. 1.2.5 To characterize adverse events of RT and compare to SOC. 1.3 Exploratory Objectives 1.3.1 To evaluate overall QOL, functional status, and quality-adjusted life years between study arms. 1.3.2 To evaluate any hospitalizations (from any cause) between study arms. 1.3.3 To characterize differences in primary and secondary endpoints between study arms (a) among the represented racial and ethnic groups (e.g. Black, White, Hispanic/Latino, Asian/Pacific Islander, and Native American),(b) by sex, and (c) by health-related social needs. 1.3.4 To evaluate the heterogeneity of radiation treatment effect based on cancer-related factors (histology, criteria indicating high-risk for SRE), treatment-related factors (bone modifying agent use, radiation dose/technique), and patient demographic factors (age, sex, race, ethnicity, and health-related social needs).
Study InformationSTUDY26884
AYA Access: An Enhanced eHealth and Chat-Bot Enabled Delivery Model for Clinical Genetic Services in Community AYA Cancer Patients
To evaluate the efficacy of an enhanced eHealth and chatbot enabled delivery model to increase uptake of genetic counseling. To evaluate the efficacy of an enhanced eHealth and chatbot enabled delivery model to increase uptake of genetic testing.
Study InformationSTUDY27070
E-Care Breast Cancer Risk Assessment Study
Risk-stratified breast cancer screening is recommended by evidence-based guidelines but not systematically implemented within primary care clinics, The study objective is to evaluate the acceptability and feasibility of implementation of the E-care intervention. Our hypothesis is that greater than 80% of patients will report that the E-CARE intervention is both feasible and acceptable. Secondary objectives include to evaluate the informed decision making in breast cancer screening and risk-aligned screening.
Study InformationSTUDY27244
NRG-CC015: Harnessing E-mindfulness Approaches for Ling After Breast Cancer - HEAL ABC
To determine the efficacy of Mindful Awareness Practices (MAPs) live online (LO) relative to the meditation only (MO) control group on depressive symptoms, as indicated by the difference in CES-D change score from baseline to post-intervention between the intervention and control groups. To determine the efficacy of Mindful Awareness Practices (MAPs) App relative to the meditation only (MO) control group on depressive symptoms, as indicated by the difference in CES-D change score from baseline to post-intervention between the intervention and control groups.
Study InformationSTUDY27547
S2417CD: A Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of an Intervention Called Current Together after Cancer (CTAC) to Promote Guideline-Concordant Colorectal Cancer Surveillance
To evaluate whether the patients randomized to the Current Together After Cancer (CTAC) intervention website compared to the CTAC control website have higher rates of guideline concordant colorectal cancer (CRC) surveillance at 12 months after registration.
Study Information