STUDY28498
A Qualitative Study Exploring the Lived Experiences of Adolescent and Young Adult Head and Neck Cancer Survivors: A Semi-Structured Interview
To explore the lived experiences of adolescent and young adult (AYA) survivors of head and neck cancer (HNC), focusing on how diagnosis, treatment, and survivorship have shaped their daily lives, identities, and social relationships. To describe and interpret common psychosocial, functional, and existential challenges encountered during survivorship, including issues related to communication, eating, appearance, and reintegration into peer groups.
Study Information
|
|
|
STUDY27244
NRG-CC015: Harnessing E-mindfulness Approaches for Ling After Breast Cancer - HEAL ABC
To determine the efficacy of Mindful Awareness Practices (MAPs) live online (LO) relative to the meditation only (MO) control group on depressive symptoms, as indicated by the difference in CES-D change score from baseline to post-intervention between the intervention and control groups. To determine the efficacy of Mindful Awareness Practices (MAPs) App relative to the meditation only (MO) control group on depressive symptoms, as indicated by the difference in CES-D change score from baseline to post-intervention between the intervention and control groups.
Study Information
|
|
|
STUDY26061
Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors
To evaluate the feasibility of text message-based to depression screening among cancer survivors.
Study Information
|
|
|
STUDY27901
Examining Emotional Health and Symptom Needs in Long-Term Cancer Survivors Living with Likely Incurable Cancer: Administrative Supplement to IMPACT R01
1. To examine emotional health and symptom burden survivorship needs and preferences for psychosocial intervention delivery in long-term cancer survivors living with likely incurable cancer (LTCS-ILLIC)
Study Information
|
|
|
STUDY26531
NRG-CC014 Radiation Therapy for High-Risk Asymptomatic Bone Metastases: A Pragmatic Multicenter Randomized Phase 3 Clinical Trial (Preempt)
1. OBJECTIVES
1.1 Primary Objective
To determine whether prophylactic radiation therapy (RT) to high-risk asymptomatic
bone metastases decreases the occurrence of skeletal-related events (SREs), including
pathologic fracture, spinal cord compression, and surgery to bone (not including
palliative radiation for pain only), compared to standard of care (SOC).
1.2 Secondary Objectives
1.2.1 To compare overall survival (OS) between study arms.
1.2.2 To compare occurrence of any SREs (including RT for palliation of pain) among enrolled
bone metastasis(es) between study arms.
1.2.3 To compare occurrence of hospitalizations related to any SREs in enrolled bone
metastasis(es) between study arms.
1.2.4 To compare pain-related quality of life (QOL) between study arms.
1.2.5 To characterize adverse events of RT and compare to SOC.
1.3 Exploratory Objectives
1.3.1 To evaluate overall QOL, functional status, and quality-adjusted life years between study
arms.
1.3.2 To evaluat
Study Information
|
|
|
STUDY25980
Optimizing Care for Cancer Survivors with Depression (OASIS): Project 3
Via a pilot randomized clinical trial (N=45, randomized 2:1), examine the feasibility of a digitally-enhanced stepped care approach to depression treatment among cancer survivors. Describe the efficacy of digitally-enhanced stepped depression care as compared to guideline-concordant standard care among cancer survivors.
Study Information
|
|
|
STUDY26465
Complementary Options for Symptom Management In Cancer (COSMIC): Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among a Cohort of Cancer Patients Treated in Community Oncology Clinics
To examine the association between cannabis and/ or cannabinoid use and cancer related symptoms associated monthly for one year in adults newly diagnosed with breast, colorectal, melanoma, non-hodgkin lymphoma, or non-small cell lung cancer who are planning or recently started to receive one or more systemic cancer directed therapies with chemotherapy and/or immune check point inhibitors targeting PD-1, PDL1 or CTLA-4.
Study Information
|
|
|
STUDY25353
NRG-CC012CD: Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment (Symon)
Test the effectiveness of automated telephone system management (ATSM) + telephone interpersonal counseling (TIPC) versus active control on patient level outcome of the summary toxicity index of 24 PRO-CTCAE symptoms that include depressive, anxiety, and other symptoms commonly experienced during oral anti-cancer treatment over weeks 1-12 (immediate effect) and 13-17 (sustained effect).
Study Information
|
|
|
STUDY25400
Exploratory Analysis of Metastatic Gynecologic Cancer Patient Experiences of Symptom Management in a Diverse Southeastern Population
The purpose of this study is to explore how socioeconomic status, race, and clinical variables affect gynecologic cancer patients perceived experiences with symptom management. The goal of this analysis is to understand patients undergoing cancer directed therapy who are underrepresented in clinical trials experience with symptom management and symptom burden.
Hypothesis: Demographic and socioeconomic data in patients undergoing treatment for metastatic gynecologic cancer will have unique perceived experiences regarding their symptom management. These experiences will change how patients interact with the healthcare system as indicated by direct clinical variables such as direct admissions to the hospital for symptom management and prescribing factors.
Study Information
|
|
|
STUDY18274
A Multi Site Randomized Clinical Trial Comparing a Brief Tele Cognitive Behavioral Therapy Intervention (BRIGHT) with Attention Control for the Management of Body Image Related Distress Among Head and Neck Cancer Survivors
To evaluate the efficacy of BRIGHT compared with attention control (AC) on HNC-related BID as measured by change from baseline in the IMAGEHN score.
Study Information
|
|
|
STUDY17550
Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS)
To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the Brief Pain Inventory (BPI)) and pain interference (also measured by the BPI) from baseline to the post-intervention assessment for cancer survivors with persistent pain.
Study Information
|
|
|
STUDY12888
The Impact of a Gravity versus Vacuum Based Indwelling Tunneled Pleural Drainage System on Pain: A Multicenter, Randomized Trial
The objective of this investigation is to compare different drainage strategies of Indwelling Pleural Catheters (IPC) regarding patient quality of life and outcomes
Study Information
|
|
|
STUDY12902
Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline Related Cardiomyopathy
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.
Study Information
|
|
|
STUDY26519
Empathic Communication Skills Training to Reduce Lung Cancer Stigma
To evaluate the effect of the ECS training on OCP primary outcomes (communication and
empathic skill uptake) and secondary outcomes (ECS training appraisal relevance, novelty, clarity; self-efficacy, empathy, compassion burn-out); to evaluate the effect of the ECS training vs. WLC on patients reported primary outcomes (lung cancer stigma), and secondary outcomes (perceived clinician empathy, satisfaction with communication, psychological distress, patients experience of clinical encounter, and overall patient satisfaction). Additionally, acceptance of referral to tobacco cessation (for those currently smoking) will be explored; and to examine potential moderators of OCP (e.g., demographic characteristics, professional role characteristics) and patient outcomes (e.g., demographic characteristics, illness characteristics).
Study Information
|
|
|
STUDY29217
Optimizing Clinical Screening for Body Image Distress Among Head and Neck Cancer Survivors: Implementation of a Short Form of the IMAGE-HN Questionnaire
The overarching goal of this study is to determine the most effective and practical approach to screen for BID among HNC survivors in the clinical setting. This includes identifying efficient methods that integrate seamlessly into routine clinic workflows while accurately detecting patients with clinically significant BID, enabling timely referral to appropriate psychosocial interventions.
Study Information
|
|
|
STUDY29165
Pilot Randomized Trial Evaluating Resistance Exercise Training and Creatine Supplementation in Individuals Treated for Head and Neck Cancer
To evaluate the feasibility, acceptability, and safety of a 10-week hybrid RT program combined with creatine monohydrate supplementation in HNC survivors.
Study Information
|
|
|
STUDY27547
S2417CD: A Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of an Intervention Called Current Together after Cancer (CTAC) to Promote Guideline-Concordant Colorectal Cancer Surveillance
To evaluate whether the patients randomized to the Current Together After Cancer (CTAC) intervention website compared to the CTAC control website have higher rates of guideline concordant colorectal cancer (CRC) surveillance at 12 months after registration.
Study Information
|
|
|
STUDY26884
AYA Access: An Enhanced eHealth and Chat-Bot Enabled Delivery Model for Clinical Genetic Services in Community AYA Cancer Patients
To evaluate the efficacy of an enhanced eHealth and chatbot enabled delivery model to increase uptake of genetic counseling. To evaluate the efficacy of an enhanced eHealth and chatbot enabled delivery model to
increase uptake of genetic testing.
Study Information
|
|
|
STUDY25488
Priorities, Preferences, and Tradeoffs Among Older Adults with Oropharyngeal Cancer
To characterize the impact of aging and multimorbidity on treatment priorities and preferences among patients with OPC.
Study Information
|
|
|
STUDY25004
Improving Proactive Approaches for Cancer Survivors' Mental Health Treatment
To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on depression symptom severity among ILLIC with depression as measured by the change in the PHQ-9 score from baseline. To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on anxiety and quality of life among ILLIC with depression as determined by the (1) change in the Hospital Anxiety and Depression Scale, Anxiety subscale score from baseline and (2) change in the Functional Assessment of Cancer Therapy-General score from baseline.
Study Information
|
|
|
STUDY25923
A Stepped-Wedge Randomized Trial Using Multi-Faceted Surgeon-Focused Education to Evaluate the Impact of a Decision Support Tool and VTE-related Pre-Discharge Education to Increase Adherence to Guideline-Concordant Extended Venous Thromboembolism Prophylaxis After Major Abdominopelvic Cancer Surgery.
Characterize barriers and facilitators to ePpx guideline adherence as perceived by stakeholders via key informant interviews with a diverse group of patients and surgeons at four hospitals within the MUSC Health system that routinely perform abdominopelvic cancer surgery. Conduct a stepped-wedge randomized trial including multi-faceted surgeon-focused education and academic detailing to evaluate the impact of an EMR-based CDSS to increase adherence to ePpx guidelines at the three selected hospitals.
Study Information
|
|
|
STUDY22933
A Stepped Wedge Cluster Randomized Trial Comparing a Navigation-Based Multilevel Intervention With Treatment as Usual to Improve Initiation of Timely Postoperative Radiation Therapy in Adults with Locally Advanced Head and Neck Squamous Cell Carcinoma (The ENDURE Trial)
Primary Objective:
1. To evaluate the effectiveness of ENDURE compared with TAU on the initiation of timely, guideline-adherent PORT among patients with LAHNSCC undergoing surgical therapy with a pathologic indication for PORT as measured by the proportion of patients who initiate PORT within 6 weeks of surgery.
Secondary Objectives:
1. To evaluate the effectiveness of ENDURE compared with TAU on the timely initiation of PORT among patients with LAHNSCC undergoing surgical therapy with a pathologic indication for PORT as determined by (1) median time-to-PORT initiation following surgery and (2) treatment package time.
2. To assess the effectiveness of ENDURE compared with TAU on racial disparities in the timely initiation of PORT among Black and White patients with LAHNSCC undergoing surgical therapy with a pathologic indication for PORT as determined by (1) the proportion of patients who initiate PORT within 6 weeks of surgery; (2) median time-to-PORT initiation following surgery;
Study Information
|
|
|
STUDY19497
A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivor Caregiver Dyads
To evaluate the effects of SNAP on: a) caregiver burden in caregivers, b) symptom severity in survivors and c) psychological well-being in head and neck cancer survivors and caregivers 6 months after completing SNAP
Study Information
|
|
|
STUDY27022
Evaluating the Impact of TrialTalk to Foster Equitable Cancer Care Delivery and Clinical Trial Participation
Examine TrialTalk effectiveness by examining the changes in clinical tiral accrual from baseline by race and ethnicity among enrolled providers and at the institution level up to 12 months post- implementation. Examine the implementation outcomes of TrialTalk such as adoption, penetration, fidelity, feasibility, and acceptability with different stakeholder groups.
Study Information
|
|
|
STUDY29131
PRIMary care Engagement in Survivorship (PRIMES): A Mixed Methods Study
Characterize primary care, oncology, and CRC survivor perspectives on strategies to address role clarity, communication, and coordination. Develop and refine a blueprint of PRIMES, a multi-level, technology-enabled intervention to improve shared survivorship care.
Study Information
|
|
|