Supportive Care Trials
Every treatment that has ever made a difference in cancer care was once a part of a clinical trial. MUSC Hollings Cancer Center is committed to offering the best treatments available today while searching for even better ones for the future. Ask your doctor if a clinical trial is right for you.
STUDY19497
A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivor-Caregiver Dyads
To evaluate the effects of SNAP on: a) caregiver burden in caregivers, b) symptom severity in survivors and c) psychological well-being in head and neck cancer survivors and caregivers 6 months after completing SNAP
Study InformationSTUDY18274
A Multi-Site Randomized Clinical Trial Comparing a Brief Tele-Cognitive Behavioral Therapy Intervention (BRIGHT) with Attention Control for the Management of Body Image-Related Distress Among Head and Neck Cancer Survivors
To evaluate the efficacy of BRIGHT compared with attention control (AC) on HNC-related BID as measured by change from baseline in the IMAGEHN score.
Study InformationSTUDY25004
IMproving Proactive Approaches for Cancer survivors' mental health Treatment
To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on depression symptom severity among ILLIC with depression as measured by the change in the PHQ-9 score from baseline. To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on anxiety and quality of life among ILLIC with depression as determined by the (1) change in the Hospital Anxiety and Depression Scale, Anxiety subscale score from baseline and (2) change in the Functional Assessment of Cancer Therapy-General score from baseline.
Study InformationSTUDY24703
Dual use of combustible and electronic cigarettes: A fine-grained naturalistic cohort study to investigate dynamic use patterns and trajectories that lead to smoking cessation
Aim 1: Describe day-to-day variability and longitudinal trajectories in tobacco product use and abstinence over time within cohorts of dual users, exclusive cigarette smokers, and exclusive e-cigarette users. Aim 1 is purely descriptive but will use rigorous methods to: 1) illustrate e-cigarette and cigarette use behaviors (using pixel graphs), 2) quantify dynamic variability in e-cigarette and cigarette use (using dynamic structural equation modeling; DSEM), and 3) classify profiles of cigarette and e-cigarette use dynamics (using latent profile analysis; LPA), each done: a) rigorously for 3 months and b) episodically across monthly 7-day serial bursts over 1 year. Aim 2: Compare variability of tobacco use patterns between dual users, exclusive cigarette smokers, and exclusive e-cigarette users. Hyp 2a: Comparing DSEM parameters identified in Aim 1, dual users will have greater variability in days of cigarette smoking vs. abstinence than exclusive smokers and (Hyp 2b) greater variability in days of e-cigarette use vs. abstinence than exclusive e-cigarette users. Aim 3: Among dual users alone, identify patterns of e-cigarette use that predict cigarette abstinence. Hyp 3a: Comparing LPA groups identified in Aim 1, profiles involving greater magnitude and consistency of e-cigarette use during the initial 3-months of nightly surveys will predict greater CO-verified 7-day point-prevalence cigarette abstinence at the 6- and 12-month follow-ups. Hyp 3b: The same e-cigarette use characteristics during the initial 3-months will be positively associated with number of days of cigarette abstinence from months 4 - 12. Exploratory: E-cigarette characteristics (device, % nicotine, flavor) and/or cannabis use may moderate findings.
Study InformationSTUDY26519
Empathic Communication Skills Training to Reduce Lung Cancer Stigma
To evaluate the effect of the ECS training on OCP primary outcomes (communication and empathic skill uptake) and secondary outcomes (ECS training appraisal relevance, novelty, clarity; self-efficacy, empathy, compassion burn-out); to evaluate the effect of the ECS training vs. WLC on patients reported primary outcomes (lung cancer stigma), and secondary outcomes (perceived clinician empathy, satisfaction with communication, psychological distress, patients experience of clinical encounter, and overall patient satisfaction). Additionally, acceptance of referral to tobacco cessation (for those currently smoking) will be explored; and to examine potential moderators of OCP (e.g., demographic characteristics, professional role characteristics) and patient outcomes (e.g., demographic characteristics, illness characteristics).
Study InformationSTUDY26932
LiveWell: An Adapted Dialectical Behavioral Therapy Skills Training Protocol for Patients Living with Metastatic Lung Cancer
To evaluate the feasibility and acceptability of LiveWell. To evaluate preliminary efficacy of LiveWell to reduce psychological distress (primary outcome) and improve psychological well-being, symptom burden, and quality of life (secondary outcomes) in patients with metastatic lung cancer compared to usual care. Exploratory: To evaluate emotion regulation as a moderator.
Study InformationSTUDY27244
NRG-CC015: Harnessing E-mindfulness Approaches for Living After Breast Cancer - HEAL ABC
To determine the efficacy of Mindful Awareness Practices (MAPs) live online (LO) relative to the meditation only (MO) control group on depressive symptoms, as indicated by the difference in CES-D change score from baseline to post-intervention between the intervention and control groups. To determine the efficacy of Mindful Awareness Practices (MAPs) App relative to the meditation only (MO) control group on depressive symptoms, as indicated by the difference in CES-D change score from baseline to post-intervention between the intervention and control groups.
Study InformationSTUDY28147
Characterizing Dyadic Communication Challenges and Support Needs in Young Adults Caring for a Parent with Metastatic Cancer
1. To characterize communication challenges and support needs within the dyad of emerging and young adult caregivers (EYAC; age 18-35) and their parents with metastatic cancer (parent metavivor). 2. To explore distress, unmet support needs, dyadic coping, communication patterns, and quality of life in EYACs and parent metavivors.
Study InformationSTUDY28303
Safely Optimizing Body Weight with TCMCB07 in Patients with Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy
To evaluate the effect of B07 relative to placebo on body weight over 12 weeks in newly diagnosed metastatic colorectal cancer patients. To evaluate the safety of B07 relative to placebo through Week 12.
Study InformationSTUDY28498
A Qualitative Study Exploring the Lived Experiences of Adolescent and Young Adult Head and Neck Cancer Survivors: A Semi-Structured Interview
To explore the lived experiences of adolescent and young adult (AYA) survivors of head and neck cancer (HNC), focusing on how diagnosis, treatment, and survivorship have shaped their daily lives, identities, and social relationships. To describe and interpret common psychosocial, functional, and existential challenges encountered during survivorship, including issues related to communication, eating, appearance, and reintegration into peer groups.
Study Information