Supportive Care Trials
Every treatment that has ever made a difference in cancer care was once a part of a clinical trial. MUSC Hollings Cancer Center is committed to offering the best treatments available today while searching for even better ones for the future. Ask your doctor if a clinical trial is right for you.
STUDY17550
Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS)
To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the Brief Pain Inventory (BPI)) and pain interference (also measured by the BPI) from baseline to the post-intervention assessment for cancer survivors with persistent pain.
Study InformationSTUDY12888
The Impact of a Gravity versus Vacuum Based Indwelling Tunneled Pleural Drainage System on Pain: A Multicenter, Randomized Trial
The objective of this investigation is to compare different drainage strategies of Indwelling Pleural Catheters (IPC) regarding patient quality of life and outcomes
Study InformationSTUDY19497
A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning Tool for Head and Neck Cancer Survivor-Caregiver Dyads
To evaluate the effects of SNAP on: a) caregiver burden in caregivers, b) symptom severity in survivors and c) psychological well-being in head and neck cancer survivors and caregivers 6 months after completing SNAP
Study InformationSTUDY18274
A Multi Site Randomized Clinical Trial Comparing a Brief Tele Cognitive Behavioral Therapy Intervention (BRIGHT) with Attention Control for the Management of Body Image Related Distress Among Head and Neck Cancer Survivors
To evaluate the efficacy of BRIGHT compared with attention control (AC) on HNC-related BID as measured by change from baseline in the IMAGEHN score.
Study InformationSTUDY25004
Improving Proactive Approaches for Cancer Survivors' Mental Health Treatment
To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on depression symptom severity among ILLIC with depression as measured by the change in the PHQ-9 score from baseline. To examine the effectiveness of proactive ID + DMHI compared with proactive ID + UC on anxiety and quality of life among ILLIC with depression as determined by the (1) change in the Hospital Anxiety and Depression Scale, Anxiety subscale score from baseline and (2) change in the Functional Assessment of Cancer Therapy-General score from baseline.
Study InformationSTUDY24703
Dual use of combustible and electronic cigarettes: A fine grained naturalistic cohort study to investigate dynamic use patterns and trajectories that lead to smoking cessation
Aim 1: Describe day-to-day variability and longitudinal trajectories in tobacco product use and abstinence over time within cohorts of dual users, exclusive cigarette smokers, and exclusive e-cigarette users. Aim 1 is purely descriptive but will use rigorous methods to: 1) illustrate e-cigarette and cigarette use behaviors (using pixel graphs), 2) quantify dynamic variability in e-cigarette and cigarette use (using dynamic structural equation modeling; DSEM), and 3) classify profiles of cigarette and e-cigarette use dynamics (using latent profile analysis; LPA), each done: a) rigorously for 3 months and b) episodically across monthly 7-day serial bursts over 1 year. Aim 2: Compare variability of tobacco use patterns between dual users, exclusive cigarette smokers, and exclusive e-cigarette users. Hyp 2a: Comparing DSEM parameters identified in Aim 1, dual users will have greater variability in days of cigarette smoking vs. abstinence than exclusive smokers and (Hyp 2b) greater variability in days of e-cigarette use vs. abstinence than exclusive e-cigarette users. Aim 3: Among dual users alone, identify patterns of e-cigarette use that predict cigarette abstinence. Hyp 3a: Comparing LPA groups identified in Aim 1, profiles involving greater magnitude and consistency of e-cigarette use during the initial 3-months of nightly surveys will predict greater CO-verified 7-day point-prevalence cigarette abstinence at the 6- and 12-month follow-ups. Hyp 3b: The same e-cigarette use characteristics during the initial 3-months will be positively associated with number of days of cigarette abstinence from months 4 - 12. Exploratory: E-cigarette characteristics (device, % nicotine, flavor) and/or cannabis use may moderate findings.
Study InformationSTUDY25980
Optimizing Care for Cancer Survivors with Depression (OASIS): Project 3
Via a pilot randomized clinical trial (N=45, randomized 2:1), examine the feasibility of a digitally-enhanced stepped care approach to depression treatment among cancer survivors. Describe the efficacy of digitally-enhanced stepped depression care as compared to guideline-concordant standard care among cancer survivors.
Study InformationSTUDY26061
Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors
To evaluate the feasibility of text message-based to depression screening among cancer survivors.
Study InformationSTUDY26247
Pilot Feasibility Trial to Evaluate a Technology-Enabled Approach to Enhance Depression Referral Uptake Among Cancer Survivors
To evaluate the feasibility and acceptability of a technology-enabled approach to improve referral uptake among cancer survivors.
Study InformationSTUDY26531
NRG-CC014 Radiation Therapy for High-Risk Asymptomatic Bone Metastases: A Pragmatic Multicenter Randomized Phase 3 Clinical Trial (Preempt)
1. OBJECTIVES 1.1 Primary Objective To determine whether prophylactic radiation therapy (RT) to high-risk asymptomatic bone metastases decreases the occurrence of skeletal-related events (SREs), including pathologic fracture, spinal cord compression, and surgery to bone (not including palliative radiation for pain only), compared to standard of care (SOC). 1.2 Secondary Objectives 1.2.1 To compare overall survival (OS) between study arms. 1.2.2 To compare occurrence of any SREs (including RT for palliation of pain) among enrolled bone metastasis(es) between study arms. 1.2.3 To compare occurrence of hospitalizations related to any SREs in enrolled bone metastasis(es) between study arms. 1.2.4 To compare pain-related quality of life (QOL) between study arms. 1.2.5 To characterize adverse events of RT and compare to SOC. 1.3 Exploratory Objectives 1.3.1 To evaluate overall QOL, functional status, and quality-adjusted life years between study arms. 1.3.2 To evaluate any hospitalizations (from any cause) between study arms. 1.3.3 To characterize differences in primary and secondary endpoints between study arms (a) among the represented racial and ethnic groups (e.g. Black, White, Hispanic/Latino, Asian/Pacific Islander, and Native American),(b) by sex, and (c) by health-related social needs. 1.3.4 To evaluate the heterogeneity of radiation treatment effect based on cancer-related factors (histology, criteria indicating high-risk for SRE), treatment-related factors (bone modifying agent use, radiation dose/technique), and patient demographic factors (age, sex, race, ethnicity, and health-related social needs).
Study Information